?-helical CRF (9-41)
£175.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
CRF antagonist.
α-helical CRF (9-41) is a corticotropin releasing factor receptor (CRF) antagonist with Ki values of 17, 5 and 0.97 nM at human CRF1, rat CRF2 and mouse CRF2 receptors respectively. α-helical CRF (9-41) decreases anxiety-like behaviour in the conditioned fear test and reverses the potentiation of startle amplitude produced by administration of CRF in anxiety models. α-helical CRF (9-41) pre-treatment blocks CRF induced food intake inhibition.
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Additional information
| Other Names | α-helical-Corticotropin-Releasing Factor 9-41, AHCRF, ah-CRF(9 “41) |
|---|---|
| Three Letter Sequence | H-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2 |
| Molecular Weight | 3827 |
| Molecular Formula | C166H274N46O53S2 |
| Sequence | DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2 |
| Solubility | Soluble to 1 mg/ml in 0.1% TFA |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | α-helical CRF 9-41, α-helical CRF (9-41), 90880-23-2, AHCRF, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA |