Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

CXCL12/HMGB1 heterocomplex inhibitor.

HBP08 is a selective inhibitor of the CXCL12/HMGB1 interaction, which binds to HMGB1 (high mobility group box1) with a Kd of 0.8 M. HMGB1 is a nonhistone nuclear protein, which acts as a DNA chaperone, contributing to gene transcription and DNA repair, and is released under stress conditions when it forms a heterocomplex with CXCL12. This heterocomplex acts on the chemokine receptor CXCR4, enhancing cell migration, and in some pathological conditions, exacerbating the immune response. HBP08 ?disruption of this heterocomplex can diminish excessive cell influx at inflammatory sites.

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