Fz7-21
£99.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Selective FZD7 antagonist.
Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt -catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation and the architecture of its lipid-binding groove. Fz7-21 antagonises Wnt -catenin signalling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of ?-catenin in mouse L cells. FzD7-21 impairs stem cell function in intestinal organoids.
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Additional information
| Other Names | FZD7-binding peptide |
|---|---|
| Three Letter Sequence | Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2 |
| Molecular Weight | 1796.05 |
| Molecular Formula | C83H114N18O23S2 |
| Sequence | Ac-LPSDDLEFWCHVMY-NH2 |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N terminal acetyl, C terminal amide |
| Searchable Words | Fz7-21, Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- |