TAT-AKAP79 (326-336)
£145.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
The key region of AKAP79 for interaction with TRPV1.
TAT-AKAP79 (326-336) is amino acids 326 336 of A-kinase anchoring protein 79 (AKAP79), the human anchoring protein, fused to TAT to promote uptake across the cell membrane. AKAP79 (326-336) is the key region of AKAP79 for interaction with transient receptor potential vanilloid 1 (TRPV1), the thermo-TRP ion channel activated by painful levels of heat, and AKAP79 binding to TRPV1 blocks TRPV1 sensitization. TAT-AKAP79 (326-336) inhibits inflammatory hyperalgesia in mice.
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Additional information
| Three Letter Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Ser-Lys-Ser-Glu-Glu-Ser-Lys-Arg-Met-Glu-OH |
|---|---|
| Molecular Weight | 2880.34 |
| Molecular Formula | C117H211N49O34S1 |
| Sequence | YGRKKRRQRRRKSKSEESKRME |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | TAT-AKAP79 (326-336), H-YGRKKRRQRRRKSKSEESKRME-OH, YGRKKRRQRRRKSKSEESKRME, A-kinase anchoring protein 79, AKAP79, transient receptor potential vanilloid 1 , TRPV1, hyperalgesia in mice, PP-130 |