PKI (14-22) amide, myristoylated
£55.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Cell permeable protein kinase A inhibitor.
PKI (14 – 22) amide, myristoylated, is a cell-permeable version of the protein kinase inhibitor (PKI) PKI (14-22) amide. When non-myristoylated, PKI (14-22) amide inhibits protein kinase A with a Ki of 36 nM and also inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1). Myristoylated peptides as a class may exhibit off-target activation of the funny current If in sinoatrial myocytes.
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Additional information
| Three Letter Sequence | Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 |
|---|---|
| Molecular Weight | 1209.5 |
| Molecular Formula | C53H100N20O12 |
| Sequence | Myr-GRTGRRNAI-NH2 |
| Solubility | Soluble in dilute acid and DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Myristoyl at N terminal, amide at C terminal |
| Searchable Words | 201422-03-9, Myr-GRTGRRNAI-NH2, GRTGRRNAI, PKI (14 – 22) amide, myristoylated, cell-permeable, protein kinase inhibitor, PKI, PKI (14-22) amide, protein kinase A, KS-110, KS110 |