F1
£175.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Blocks the association of IKKbeta and NEMO.
F1 is a peptide derived from amino acids 46-60 of IkB kinase (IKK) interacting protein (IKIP) fused to a TAT cell penetrating peptide. F1 peptide specifically interacts with IKKalpha/beta to block association with the regulatory subunit NEMO, also known as
IKKgamma, thereby inhibiting the phosphorylation of IKKalpha/beta and the activation of NF-kB. F1 reduces LPS induced acute inflammation and attenuates Zymosan-induced acute arthritis in mice.
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Additional information
| Other Names | F1 peptide, TAT-IKIP (46-60) |
|---|---|
| Three Letter Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Leu-Ser-Leu-Ala-Met-Thr-Leu-Gly-Leu-Ala-Trp-Leu-Val-Phe-OH |
| Molecular Weight | 3189.91 |
| Molecular Formula | C145H246N48O31S |
| Sequence | YGRKKRRQRRRLLSLAMTLGLAWLVF |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | F1, PP-220, PP220, YGRKKRRQRRRLLSLAMTLGLAWLVF |