Z-VAD-FMK
£95.00 1mg
Pan-caspase inhibitor.
Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing and apoptosis induction in tumour cells in vitro with an IC50 of 0.0015 – 5.8 mM). Z-VAD-FMK is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Z-VAD-FMK is active in vivo and can inhibit apoptosis in numerous settings.
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Additional information
| Other Names | Z-Val-Ala-Asp(OMe)-FMK |
|---|---|
| Three Letter Sequence | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone |
| Molecular Weight | 467.49 |
| Molecular Formula | C22H30FN3O7 |
| Sequence | Z-VAD-FMK |
| Solubility | Soluble to 10 mg/mL in DMSO |
| Appearance | White lyophilised solid |
| Storage | Store dry, dark and frozen |
| Purity | >98% by TLC |
| Modifications | Benzyloxycarbonyl (Z) at N terminal, Fluoromethylketone (FMK) at C terminal |
| Searchable Words | Z-VAD-FMK, Z-Val-Ala-Asp(OMe)-FMK, cell-permeable, caspase inhibitor, 187389-52-2, PI-250, PI250 |