Z-VAD-FMK

£95.00 1mg

Pan-caspase inhibitor.

Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing and apoptosis induction in tumour cells in vitro with an IC50 of 0.0015 – 5.8 mM). Z-VAD-FMK is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Z-VAD-FMK is active in vivo and can inhibit apoptosis in numerous settings.

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SKU: PI-250 Categories: ,

Additional information

Other Names

Z-Val-Ala-Asp(OMe)-FMK

Three Letter Sequence

Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone

Molecular Weight

467.49

Molecular Formula

C22H30FN3O7

Sequence

Z-VAD-FMK

Solubility

Soluble to 10 mg/mL in DMSO

Appearance

White lyophilised solid

Storage

Store dry, dark and frozen

Purity

>98% by TLC

Modifications

Benzyloxycarbonyl (Z) at N terminal, Fluoromethylketone (FMK) at C terminal

Searchable Words

Z-VAD-FMK, Z-Val-Ala-Asp(OMe)-FMK, cell-permeable, caspase inhibitor, 187389-52-2, PI-250, PI250