Z-DEVD-FMK

£145.00 1mg

Cell-permeable, irreversible caspase-3 inhibitor.

Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3 with an IC50 of 0.13 M and no activity at cathepsin B and cathepsin L. Z-DEVD-FMK inhibits apoptotic cell death in many cell types including cancer cells, it is neuroprotective in rat hippocampus following seizures in vivo and local application of Z-DEVD-FMK after spinal cord injury in rats reduces secondary tissue injury and helps preserve motor function.

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SKU: CS-010 Categories: ,

Additional information

Other Names

Z-DEVD-fluoromethyl ketone, z-DEVD.fmk

Three Letter Sequence

Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone

Molecular Weight

668.67

Molecular Formula

C30H41FN4O12

Sequence

DEVD

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone

Searchable Words

Z-DEVD-FMK, Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone, DEVD, Z-DEVD-fluoromethyl
ketone, 210344-95-9, CS-010