WRW4

£75.00 1mg

SKU: FR-020 Categories: ,

Selective formyl peptide receptor 2 (FPR2) antagonist.

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signalling, which can inhibit WKYMVm binding to FPR2 with an C50 of 0.23 μM and can also inhibit intracellular calcium release induced by WKYMVm, MMK 1, amyloid 42, and F peptide. WRW4 inhibits FPR2-mediated signalling in human neutrophils and blocks chemotactic migration and superoxide generation by amyloid 42 peptide. WRW4 can reduce Brucella proliferation in animal models.

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Additional information

Three Letter Sequence

H-Trp-Arg-Trp-Trp-Trp-Trp-NH2

Molecular Weight

1104.28

Molecular Formula

C61H65N15O6

Sequence

WRWWWW-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

WRW4, 878557-55-2, WRWWWW-NH2, FR-020