WP 1130
£85.00 10mg
Deubiquitinase (DUB) inhibitor.
WP 1130, also known as degrasyn, is a cell-permeable deubiquitinase (DUB) inhibitor, able to directly inhibit the DUB activity of USP9x, USP5, USP14, and UCH37. WP 1130 has been shown to downregulate both wild-type and mutant Bcr/Abl without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. WP 1130 can cause marked anti-proliferative activity and morphological changes in NCH644 and NCH421K glioma stem-like cells.
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Additional information
Other Names | Degrasyn |
---|---|
Three Letter Sequence | (2E)‹-3-‹(6-‹bromo-‹2-‹pyridinyl)‹-‹2-‹cyano-‹N-‹[1S-‹phenylbutyl]‹-2-‹propenamide |
Molecular Weight | 384.3 |
Molecular Formula | C19H18BrN3O |
Sequence | (2E)‹-3-‹(6-‹bromo-‹2-‹pyridinyl)‹-‹2-‹cyano-‹N-‹[1S-‹phenylbutyl]‹-2-‹propenamide |
Solubility | Soluble in DMSO and ethanol |
Appearance | White solid |
Storage | Store desiccated, frozen and in the dark |
Purity | >98% by HPLC |