WP 1130

£85.00 10mg

Deubiquitinase (DUB) inhibitor.

WP 1130, also known as degrasyn, is a cell-permeable deubiquitinase (DUB) inhibitor, able to directly inhibit the DUB activity of USP9x, USP5, USP14, and UCH37. WP 1130 has been shown to downregulate both wild-type and mutant Bcr/Abl without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. WP 1130 can cause marked anti-proliferative activity and morphological changes in NCH644 and NCH421K glioma stem-like cells.

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SKU: PI-240 Categories: ,

Additional information

Other Names

Degrasyn

Three Letter Sequence

(2E)‹-3-‹(6-‹bromo-‹2-‹pyridinyl)‹-‹2-‹cyano-‹N-‹[1S-‹phenylbutyl]‹-2-‹propenamide

Molecular Weight

384.3

Molecular Formula

C19H18BrN3O

Sequence

(2E)‹-3-‹(6-‹bromo-‹2-‹pyridinyl)‹-‹2-‹cyano-‹N-‹[1S-‹phenylbutyl]‹-2-‹propenamide

Solubility

Soluble in DMSO and ethanol

Appearance

White solid

Storage

Store desiccated, frozen and in the dark

Purity

>98% by HPLC