VPM-p15

£175.00 1mg

GPR64 (ADGRG2) agonist.

VPM-p15 is an optimised version of the peptide p15, itself an activator derived from the ADGRG2 Stachel sequence, an agonist sequence found within the large ectodomains of members of the adhesion G protein-coupled receptor (aGPCR) family. VPM-p15 activates ADGRG2 with significantly improved (>2 orders of magnitude) affinity compared to p15. VPM-p15 is a useful tool to investigate the function of ADGRG2, which is a critical regulator of male fertility that maintains ion/pH homeostasis and CFTR coupling.

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SKU: OR-020 Categories: ,

Additional information

Other Names

T1V/F3Phe(4-Me)

Three Letter Sequence

H-Val-Ser-Phe(4-Me)-Gly-Ile-Leu-Leu-Asp-Leu-Ser-Arg-Thr-Ser-Leu-Pro-OH

Molecular Weight

1631.91

Molecular Formula

C75H126N18O22

Sequence

VSXGILLDLSRTSLP

Solubility

Soluble in DMSO and physiological buffers

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

X is 4-methylphenylalanine

Searchable Words

VPM-p15, OR-020, OR020, VSXGILLDLSRTSLP, T1V/F3Phe(4-Me)