Vildagliptin

£45.00 10mg

Dipeptidyl peptidase IV (DPP-IV) inhibitor.

Vildagliptin, also known as LAF237, is a potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin inhibits the inactivation of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) by DPP-IV, allowing GLP-1 and GIP to potentiate the secretion of insulin and suppress glucagon release in the pancreas. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity in type 2 diabetes.

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SKU: PI-230 Categories: ,

Additional information

Other Names

LAF237

Three Letter Sequence

1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile

Molecular Weight

303.4

Molecular Formula

C17H25N3O2

Sequence

1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile

Solubility

Soluble in water

Appearance

White solid

Storage

Store desiccated, frozen and in the dark

Purity

98% by TLC