UFP 101

£155.00 1mg

Potent and selective nociceptin receptor antagonist.

UFP 101 is a potent, selective and competitive antagonist at the nociceptin receptor. UFP 101 binds to nociceptin receptors with high affinity (pKi 10.24) and possesses ~3000 fold selectivity over the classical opioid receptors. UFP 101 is antinociceptive and opposes the action of nociceptin in vivo, with an antinociceptive effect when given i.c.v. while being inactive following spinal administration in mice. UFP 101 also shows antidepressant effects in distinct species and can reduce microvascular inflammation to lipopolysaccharide in vivo.

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SKU: NO-010 Categories: ,

Additional information

Other Names

[Nphe1,Arg14,Lys15]nociceptin-NH2, [Nphe1, Arg14, Lys15] N/OFQ NH2

Three Letter Sequence

Bn-Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-NH2

Molecular Weight

1908.19

Molecular Formula

C82H138N32O21

Sequence

Bn-GGGFTGARKSARKRKNQ-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N-terminal benzyl, C-terminal amide

Searchable Words

UFP 101, UFP-101, [Nphe1,Arg14,Lys15]nociceptin-NH2, 849024-68-6, [Nphe1, Arg14, Lys15] N/OFQ NH2, NO-010