Members of this class of antibiotic inhibit protein synthesis by binding to the 30S ribosomal subunit, thereby blocking the incoming aminoacyl- tRNA from attaching to the acceptor site on the mRNAribosome complex. The tetracyclines consist of a polycyclic ring with differing side chains and are a broadspectrum class of antibiotics against aerobes and anaerobes. The effect of this bacteriostatic compound is reduced by dilution, and its activity can be reduced by chelation with divalent cations.

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