Tertiapin

£225.00 1mg

Selective IKACh blocker.

Tertiapin is a peptide found in the venom of the European honey bee (Apis mellifera). Tertiapin is a selective inhibitor of the G-protein-gated atrial K+ channel IKACh that can prolong atrial effective refractory period and terminate atrial fibrillation. Tertiapin is also a selective and potent inhibitor of muscarinic K+ channels in rabbit cardiac myocytes. The methionine residue at position 13 of tertiapin is sensitive to oxidation, reducing ability to block ion channels, so the methionine may be substituted by glutamine in order to prevent oxidation, resulting in tertiapin-Q, which shows no functional chan and is a more suitable research tool for some applications.

SKU: KC-020 Categories: ,

Additional information

Other Names

TPN

Three Letter Sequence

H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2; disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18

Molecular Weight

2455.07

Molecular Formula

C106H176N34O23S5

Sequence

ALCNCNRIIIPHMCWKKCGKK-NH2

Solubility

Soluble in water to 1 mg/m

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark. Protect from air.

Purity

>95% by HPLC

Modifications

Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide

Searchable Words

Tertiapin, 403843-29-8, ALCNCNRIIIPHMCWKKCGKK-NH2, ALCNCNRIIIPHMCWKKCGKK