Tertiapin Q

£145.00 1mg

Inward rectifier K+ ?channel blocker.

Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels.

SKU: KC-010 Categories: ,

Additional information

Other Names

TPNQ, TPN(Q)

Three Letter Sequence

H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2: disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18

Molecular Weight

2452

Molecular Formula

C106H175N35O24S4

Sequence

ALCNCNRIIIPHQCWKKCGKK-NH2

Solubility

Soluble to 2 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide

Searchable Words

ALCNCNRIIIPHQCWKKCGKK-NH2, ALCNCNRIIIPHQCWKKCGKK, 910044-56-3, TPNQ