Tertiapin Q
£145.00 1mg
Inward rectifier K+ ?channel blocker.
Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels.
Additional information
| Other Names | TPNQ, TPN(Q) |
|---|---|
| Three Letter Sequence | H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2: disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18 |
| Molecular Weight | 2452 |
| Molecular Formula | C106H175N35O24S4 |
| Sequence | ALCNCNRIIIPHQCWKKCGKK-NH2 |
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide |
| Searchable Words | ALCNCNRIIIPHQCWKKCGKK-NH2, ALCNCNRIIIPHQCWKKCGKK, 910044-56-3, TPNQ |