Tertiapin Q
£145.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Inward rectifier K+ ?channel blocker.
Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels.
Additional information
| Other Names | TPNQ, TPN(Q) |
|---|---|
| Three Letter Sequence | H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2: disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18 |
| Molecular Weight | 2452 |
| Molecular Formula | C106H175N35O24S4 |
| Sequence | ALCNCNRIIIPHQCWKKCGKK-NH2 |
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide |
| Searchable Words | ALCNCNRIIIPHQCWKKCGKK-NH2, ALCNCNRIIIPHQCWKKCGKK, 910044-56-3, TPNQ |