Tertiapin LQ

£85.00 1mg

Selective Kir1.1 blocker.

Tertiapin LQ is a selective blocker of Kir1.1 channels, obtained by modifying tertiapin, the toxin from the honey bee venom. Tertiapin LQ blocks Kir1 with high affinity (1.1 nM) and high selectivity (>250-fold) over many commonly studied Kir subtypes. Application of tertiapin LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppresses normal performance of Purkinje cell pause responses to the conditional stimulus with no detectable effect on spontaneous firing.

SKU: KC-030 Categories: ,

Additional information

Other Names

TPNLQ, TLQ

Three Letter Sequence

H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2; disulfide bridges between cysteines 3 – 14 and 5 – 18

Molecular Weight

2428.03

Molecular Formula

C106H179N33O24S4

Sequence

ALCNCNRIIIPLQCWKKCGKK-NH2

Solubility

Soluble to 2 mg/ml in 20% acetonitrile / water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Disulfide bridges between cysteines 3 – 14, and 5 – 18, C-terminal amide

Searchable Words

Tertiapin LQ, TPNLQ