Tertiapin LQ
£85.00 1mg
Selective Kir1.1 blocker.
Tertiapin LQ is a selective blocker of Kir1.1 channels, obtained by modifying tertiapin, the toxin from the honey bee venom. Tertiapin LQ blocks Kir1 with high affinity (1.1 nM) and high selectivity (>250-fold) over many commonly studied Kir subtypes. Application of tertiapin LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppresses normal performance of Purkinje cell pause responses to the conditional stimulus with no detectable effect on spontaneous firing.
Additional information
| Other Names | TPNLQ, TLQ |
|---|---|
| Three Letter Sequence | H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2; disulfide bridges between cysteines 3 – 14 and 5 – 18 |
| Molecular Weight | 2428.03 |
| Molecular Formula | C106H179N33O24S4 |
| Sequence | ALCNCNRIIIPLQCWKKCGKK-NH2 |
| Solubility | Soluble to 2 mg/ml in 20% acetonitrile / water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Disulfide bridges between cysteines 3 – 14, and 5 – 18, C-terminal amide |
| Searchable Words | Tertiapin LQ, TPNLQ |