tcY-NH2
£125.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Selective PAR4 antagonist.
tcY-NH2 is a selective PAR4 antagonist peptide which can block platelet aggregation caused by thrombin, without affecting ADP mediated aggregation. tcY-NH-2 also blocks PAR4 activation of the ERK pathway and through this mechanism can mediate aortic vascular smooth muscle cell migration and proliferation in rat models.
Additional information
| Other Names | (trans-Cinnamoyl)-YPGKF-NH2, trans-cinnamoyl-YPGKF-NH2 |
|---|---|
| Three Letter Sequence | trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-N2 |
| Molecular Weight | 739.87 |
| Molecular Formula | C40H49N7O7 |
| Sequence | trans-Cinnamoyl-YPGKF-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide |
| Searchable Words | tcY-NH2, (trans-Cinnamoyl)-YPGKF-NH2, 327177-34-4, trans-Cinnamoyl-YPGKF-NH2 |