tcY-NH2
£125.00 1mg
Selective PAR4 antagonist.
tcY-NH2 is a selective PAR4 antagonist peptide which can block platelet aggregation caused by thrombin, without affecting ADP mediated aggregation. tcY-NH-2 also blocks PAR4 activation of the ERK pathway and through this mechanism can mediate aortic vascular smooth muscle cell migration and proliferation in rat models.
Additional information
| Other Names | (trans-Cinnamoyl)-YPGKF-NH2, trans-cinnamoyl-YPGKF-NH2 |
|---|---|
| Three Letter Sequence | trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-N2 |
| Molecular Weight | 739.87 |
| Molecular Formula | C40H49N7O7 |
| Sequence | trans-Cinnamoyl-YPGKF-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide |
| Searchable Words | tcY-NH2, (trans-Cinnamoyl)-YPGKF-NH2, 327177-34-4, trans-Cinnamoyl-YPGKF-NH2 |