Tat-?syn-degron

£175.00 1mg

?-Synuclein knockdown peptide.

Tat-?syn-degron is a blood-brain barrier and plasma membrane permeable ?-synuclein knockdown peptide which can reduce the level of
?-synuclein by proteasomal degradation. Tat-?syn-degron decreases ?-synuclein aggregates and microglial activation in an ?-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing human A53T ?-synuclein, and reduces ?-synuclein levels and significantly decreases the neuronal damage and motor impairment in a mouse toxicity model of Parkinsons disease.

Please contact us for availability.

SKU: PP-040 Categories: ,

Additional information

Other Names

Tat-?syn-degron peptide

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly-OH

Molecular Weight

3146.71

Molecular Formula

C132H237N59O31

Sequence

YGRKKRRQRRRRTKSGVYLVGRRRG

Solubility

Soluble in water

Appearance

Freeze fried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

Tat-?syn-degron, YGRKKRRQRRRRTKSGVYLVGRRRG, synuclein, parkinsons, Tat-?syn-degron, PP-040, PP040