TAT-GluR6-9c

£125.00 1mg

GluR6-PSD95 interaction blocker.

TAT-GluR6-9c is a peptide derived from the nine C terminal residues of the kainate receptor subunit GluR6, linked to the cell penetrating sequence TAT. TAT-GluR6-9c ?is able to perturb the interaction of GluR6 with postsynaptic density protein 95 (PSD-95) and suppress the assembly of the GluR6-PSD-95-mixed lineage protein kinase 3 (MLK3) signalling module, causing inhibition of c-Jun N-terminal kinase (JNK) activation. JNK has an important role during global and focal cerebral ischemia/reperfusion and consistent with JNK inhibition, TAT-GluR6-9c pretreatment decreases neuronal death induced by kainate in vitro. In vivo, TAT-GluR6-9c protects against kainate-induced epileptic seizure and has a neuroprotective effect against ischaemic brain damage, significantly decreasing neuronal degeneration.

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SKU: GL-170 Categories: ,

Additional information

Other Names

Tat-GluR6-9c

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Leu-Pro-Gly-Lys-Glu-Thr-Met-Ala-OH

Molecular Weight

2542.47

Molecular Formula

C106H191N45O26S

Sequence

YGRKKRRQRRRRLPGKETMA

Solubility

Soluble in saline

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

YGRKKRRQRRRRLPGKETMA, GL-170, GL170, TAT-GluR6-9c