TAT-Gap19

£125.00 1mg

Connexin43 hemichannel inhibitor.

TAT-Gap19 is a connexin43 (Cx43) hemichannel blocker, with an IC50 of 7 μM and no significant affinity for gap junctions or Panx1 channels. TAT-Gap19 is derived from Gap19, a sequence present on the intracellular cytoplasmic loop domain of Cx43, linked to the HIV-derived TAT internalization sequence to promote membrane permeability, which also allows brain penetration. In mouse models of liver damage, TAT-Gap19 can protect against liver fibrosis accompanied by superoxide dismutase overactivation and reduces production of inflammatory proteins.

Please contact us for availability.

SKU: GJ-040 Categories: ,

Additional information

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH

Molecular Weight

2703.28

Molecular Formula

C119H212N46O26

Sequence

YGRKKRRQRRRKQIEIKKFK

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

TAT-Gap19, TAT Gap19, 1507930-54-2, YGRKKRRQRRRKQIEIKKFK