TAT-D1 Peptide

£185.00 1mg

D1-D2 heteromer antagonist.

Tat-D1 peptide is a peptide constructed from amino acids 396 413 of the dopamine D1 receptor C tail – a sequence chosen to include amino acids 404Glu and 405Glu which were identified to interact with the dopamine D2 receptor – fused at the NH2 terminus to TAT peptide for cell permeability. TAT-D1 peptide blocks the interaction between D1 and D2 receptors, inhibiting D1-D2 heteromer expression and function without affecting other receptor oligomers such as D1-D1 homomers or D2-D5 heteromers. Tat-D1 peptide disruption of the D1-D2 heteromer abolishes its interaction with Gq and attenuates its calcium signalling and functions as a selective antagonist in vitro and in vivo. In animal models, TAT-D1 treatment alleviates behavioural despair symptoms and exerts antidepressant-like effects in rats, and in addiction models the Tat-D1 peptide reverses SKF83959-induced inhibition of amphetamine sensitization.

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SKU: DA-020 Categories: ,

Additional information

Other Names

D1 peptide

Three Letter Sequence

Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu

Molecular Weight

3472.97

Molecular Formula

C144H257N57O43

Sequence

GRKKRRQRRRPQGSSEDLKKEEAAGIARPL

Solubility

Soluble in saline

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

GRKKRRQRRRPQGSSEDLKKEEAAGIARPL, DA-020, DA020, D1 peptide, TAT-D1 peptide