Tat-CIRP

£175.00 1mg

MD2 – CIRP interaction blocker.

Tat-CIRP is a peptide derived from the high affinity binding region of cold-inducible RNA binding protein (CIRP) which competitively binds to myeloid differentiation factor 2 (MD2) and blocks the MD2-CIRP interaction. MD2 is an essential accessory protein for
Toll like receptor 4 (TLR4) activation and blocking the function of MD2 and TLR4 with Tat-CIRP is neuroprotective, reducing apoptosis and necroptosis in vitro. In vivo, Tat-CIRP is neuroprotective against ischemic and hemorrhagic stroke in mice and reduces brain infarct volume and preserves neurological function in rhesus monkeys 30 days after ischemic stroke.

Please contact us for availability.

SKU: PP-230 Categories: ,

Additional information

Other Names

Tat “cold inducible RNA binding protein

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH

Molecular Weight

2997.34

Molecular Formula

C123H206N56O33

Sequence

YGRKKRRQRRRGRGFSRGGGDRGYGG

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

YGRKKRRQRRRGRGFSRGGGDRGYGG, PP-230, PP230, H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH, Tat “cold-inducible RNA binding protein, Trans-trans-activating (Tat)-cold-inducible RNA binding protein