TAT-CBD3

£175.00 1mg

SKU: PP-140 Categories: ,

CRMP2 – CaV2.2 interaction inhibitor.

TAT-CBD3 is the 15-amino acid peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2) conjugated to the cell penetrating motif of the HIV transduction domain protein TAT, which is a modulator of N-type voltage-gated calcium channels (CaV2.2). TAT-CBD3 functions as a CRMP2 – CaV2.2 interaction inhibitor and reduces CaV2.2 mediated currents, and also reduces T-type currents, which results in reduced nociceptor excitability, diminished neuropeptide release from sensory neurons and lower excitatory synaptic transmission. TAT-CBD3 can also reduce hypersensitive behaviour in chemical-induced inflammatory and neuropathic animal pain models.

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Additional information

Three Letter Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH

Molecular Weight

3192.78

Molecular Formula

C134H243N59O32

Sequence

YGRKKRRQRRRARSRLAELRGVPRGL

Solubility

Soluble in DMSO

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

TAT-CBD3, H-YGRKKRRQRRRARSRLAELRGVPRGL-OH, YGRKKRRQRRRARSRLAELRGVPRGL, collapsin response mediator protein 2, CRMP-2, N-type voltage-gated calcium channels, CaV2.2, CRMP2 – CaV2.2 interaction, T-type currents, nociceptor, pain, PP-140