TAT-ANK
£145.00 1mg
Dll4-Notch1 inhibitor.
TAT-ANK is a peptide derived from amino acid residues 179 191 of the G-protein coupled receptor kinase interacting protein-1 (GIT1) ankyrin domain, which are crucial for GIT1 binding to the Notch transcription repressor RBP-J. In vitro application of TAT-ANK significantly inhibits Delta-like 4 (Dll4) expression and Notch 1 activation in human umbilical vein endothelial cells (HUVECs) by competing with activated Notch1 binding to RBP-J, and in mouse models, TAT-ANK reduces tumour size through impairing tumour angiogenesis.
Additional information
| Other Names | ANK peptide |
|---|---|
| Three Letter Sequence | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH |
| Molecular Weight | 2946.45 |
| Molecular Formula | C128H221N47O33 |
| Sequence | YGRKKRRQRRRQTLQAELLVVYGA |
| Solubility | Soluble in 50% DMSO and 50% sterile H2O |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | YGRKKRRQRRRQTLQAELLVVYGA, PP-270, TAT-ANK, ANK peptide |