Synstatin

£175.00 1mg

Syndecan-1 ?mediated integrin activation inhibitor.

Synstatin is a peptide derived from amino acids 92-119 of the mouse syndecan sequence and is the active site for the v3 and v5 integrin activation mechanism. Syndecan is a critical regulator of these two integrins during angiogenesis and tumourigenesis, and this activation process can be blocked by the synstatin peptide. Synstatin displays an IC50 of 100-300 nM when used in vitro to inhibit v3 dependent adhesion and cell migration on vitronectin or in aortic ring angiogenesis assays. Synstatin is a potent inhibitor of angiogenesis in vivo and blocks v3 mediated tumour cell adhesion and migration and tumour formation in mouse models.

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SKU: IG-050 Categories: ,

Additional information

Other Names

SSTN, SSTN92-119

Three Letter Sequence

H-Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu-OH

Molecular Weight

3032.31

Molecular Formula

C133H207N35O46

Sequence

LPAGEKPEEGEPVLHVEAEPGFTARDKE

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

Synstatin, IG-050, LPAGEKPEEGEPVLHVEAEPGFTARDKE, SSTN, SSTN92-119, IG050