Substance P
£85.00 1mg
Endogenous neurokinin-1 receptor (NK1R) agonist.
Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity.
Please contact us for availability.
Additional information
| Other Names | Neurokinin-1 |
|---|---|
| Three Letter Sequence | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| Molecular Weight | 1347.6 |
| Molecular Formula | C63H98N18O13S |
| Sequence | RPKPQQFFGLM-NH2 |
| Solubility | Soluble in dilute acid and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C terminal amide |
| Searchable Words | Substance P, neurokinin-1, neuropeptide, neurokinin-1 receptor, NK1R, pain transmission, inflammatory diseases, obesity, RPKPQQFFGLM, 33507-63-0, NR-140, NR140 |