Substance P

£85.00 1mg

Endogenous neurokinin-1 receptor (NK1R) agonist.

Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity.

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SKU: NR-140 Categories: ,

Additional information

Other Names

Neurokinin-1

Three Letter Sequence

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Molecular Weight

1347.6

Molecular Formula

C63H98N18O13S

Sequence

RPKPQQFFGLM-NH2

Solubility

Soluble in dilute acid and physiological buffers

Appearance

Freeze dried solid

Storage

We recommend storage desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

Substance P, neurokinin-1, neuropeptide, neurokinin-1 receptor, NK1R, pain transmission, inflammatory diseases, obesity, RPKPQQFFGLM, 33507-63-0, NR-140, NR140