st-Ht31

£125.00 1mg

AKAP-PKA interaction inhibitor.

st-Ht31 is a stearated and cell-permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein ?-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.

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SKU: KS-200 Categories: ,

Additional information

Other Names

S-Ht31, st-Ht 31 (493-515)

Three Letter Sequence

Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH

Molecular Weight

2798.27

Molecular Formula

C129H217N29O39

Sequence

Stearyl-DLIEEAASRIVDAVIEQVKAAGAY

Solubility

Soluble to 1 mg/ml in 0.01M PBS

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N-terminal stearyl

Searchable Words

st-Ht31, KS-200, KS 200, KS200, 188425-80-1, Stearyl-DLIEEAASRIVDAVIEQVKAAGAY, DLIEEAASRIVDAVIEQVKAAGAY , S-Ht31