st-Ht31
£125.00 1mg
AKAP-PKA interaction inhibitor.
st-Ht31 is a stearated and cell-permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein ?-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.
Please contact us for availability.
Additional information
| Other Names | S-Ht31, st-Ht 31 (493-515) |
|---|---|
| Three Letter Sequence | Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH |
| Molecular Weight | 2798.27 |
| Molecular Formula | C129H217N29O39 |
| Sequence | Stearyl-DLIEEAASRIVDAVIEQVKAAGAY |
| Solubility | Soluble to 1 mg/ml in 0.01M PBS |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N-terminal stearyl |
| Searchable Words | st-Ht31, KS-200, KS 200, KS200, 188425-80-1, Stearyl-DLIEEAASRIVDAVIEQVKAAGAY, DLIEEAASRIVDAVIEQVKAAGAY , S-Ht31 |