Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

AKAP-PKA interaction inhibitor.

st-Ht31 is a stearated and cell-permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein ?-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.

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