ssK36
£125.00 1mg
SET domain containing protein 2 (SETD2) super substrate.
ssK36, or ssK36 (29 ?43), is a SET-domain containing protein 2 (SETD2) super substrate. SETD2, also called KMT3A, was first identified as huntingtin interacting protein 1 (HYPB, HIP-1) and can add up to three methyl groups to K36 of histone H39 (H3K36). ssK36 (29-43 has been derived from the currently used SETD2 substrate peptide H3K36 (29-43) but is methylated about 290-fold faster, making it a super substrate. The increased methylation of ssK36 is due to an increase in the rate of catalysis and only to a smaller degree to improved binding.
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Additional information
| Other Names | ssK36 (29 “43) |
|---|---|
| Three Letter Sequence | H-Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro-OH |
| Molecular Weight | 1771 |
| Molecular Formula | C79H127N29O18 |
| Sequence | APRFGGVKRPNRYRP |
| Solubility | Soluble in water and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | ssK36, APRFGGVKRPNRYRP, H-APRFGGVKRPNRYRP-OH, ssK36 (29 “43), SETD2, substrate, SP-010, SP010 |