ssK36

£125.00 1mg

SET domain containing protein 2 (SETD2) super substrate.

ssK36, or ssK36 (29 ?43), is a SET-domain containing protein 2 (SETD2) super substrate. SETD2, also called KMT3A, was first identified as huntingtin interacting protein 1 (HYPB, HIP-1) and can add up to three methyl groups to K36 of histone H39 (H3K36). ssK36 (29-43 has been derived from the currently used SETD2 substrate peptide H3K36 (29-43) but is methylated about 290-fold faster, making it a super substrate. The increased methylation of ssK36 is due to an increase in the rate of catalysis and only to a smaller degree to improved binding.

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SKU: SP-010 Categories: ,

Additional information

Other Names

ssK36 (29 “43)

Three Letter Sequence

H-Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro-OH

Molecular Weight

1771

Molecular Formula

C79H127N29O18

Sequence

APRFGGVKRPNRYRP

Solubility

Soluble in water and physiological buffers

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

ssK36, APRFGGVKRPNRYRP, H-APRFGGVKRPNRYRP-OH, ssK36 (29 “43), SETD2, substrate, SP-010, SP010