Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Endogenous galanin receptor 2/3 agonist.

Spexin, or neuropeptide Q, is an endogenous galanin receptor 2/3 agonist with EC50 values of 45 and 112 nM respectively, and no significant activity at galanin receptor 1. Spexin is a satiety inducing peptide which inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet induced obese mice and rats. ? Spexin gene expression is markedly down regulated in obese human fat. Spexin also posseses anxiolytic properties.

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