SOR-C13
£125.00 1mg
TRPV6 antagonist.
SOR-C13 is a carboxy terminal truncated peptide derived from the 54 residue paralytic peptide soricidin, found in the paralytic venom of the short-tailed shrew Blarina brevicauda. SOR-C13 is a high affinity, use dependent antagonist of human transient receptor potential vanilloid 6 (TRPV6) channels with an IC50 of 14 nM. TRPV6 is a non-voltage gated calcium channel implicated in malignancies and poor prognosis in breast cancer. In vivo, SOR-C13 reduces the growth of human ovarian xenografts in NOD/SCID mouse models.
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Additional information
| Three Letter Sequence | H-Lys-Glu-Phe-Leu-His-Pro-Ser-Lys-Val-Asp-Leu-Pro-Arg-OH |
|---|---|
| Molecular Weight | 1565.81 |
| Molecular Formula | C72H116N20O19 |
| Sequence | KEFLHPSKVDLPR |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | SOR-C13, TP-020, 1187852-48-7, KEFLHPSKVDLPR |