Sivelestat

£75.00 5mg

Human neutrophil elastase inhibitor.

Sivelestat, also known as ONO 5046, is a competitive inhibitor of human neutrophil elastase with an IC50 of 0.044M. Sivelistat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse but does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin or cathepsin G even at 100M. Sivelistat is used in the treatment of acute respiratory failure and also improves neuropathic pain.

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SKU: PI-180 Categories: ,

Additional information

Other Names

ONO 5046

Three Letter Sequence

Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

Molecular Weight

434.46

Molecular Formula

C20H22N2O7S · xNa+ · yH2O

Sequence

Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

Solubility

Soluble in DMSO

Appearance

White solid

Storage

Store dry, dark and frozen

Purity

>95% by HPLC