SHLP2

£145.00 1mg

SKU: CK-050 Categories: ,

Binds to and activates CXCR7.

SHLP2 is one of six small human in-like peptides (SHLP1 to 6) encoded by the 16S rRNA gene of the mitochondrial DNA genome, which is implicated in several biological processes such as ageing and oxidative stress. SHLP2 induces ?-Arrestin recruitment to CXCR7 with an EC50 of 0.9696M, and also binds directly to CXCR7, causing its internalization without affecting CXCR4. In vivo, administration of SHLP2 results in the suppression of food intake, activation of thermogenesis, and prevention of diet-induced obesity in mice. Activation of pro-opiomelanocortin (POMC) neurons by SHLP2 in the arcuate nucleus of the hypothalamus is involved in these processes. SHLP2 can also improve glucose tolerance and insulin sensitivity in vivo.

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Additional information

Other Names

Small humanin-like peptide 2

Three Letter Sequence

H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH

Molecular Weight

3015.58

Molecular Formula

C142H214N36O35S

Sequence

MGVKFFTLSTRFFPSVQRAVPLWTNS

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC