SAP15

£125.00 1mg

HDAC5 inhibitor.

SAP15 is a cell penetrating peptide corresponding to the last 15 amino acids of the host defense peptide human ?-defensin 3, which is involved in adaptive immunity and pro- and anti-inflammatory responses. SAP15 is a histone deacetylase 5 (HDAC5) inhibitor with a dissociation constant of 86 nM in an SPR assay and inhibits lipopolysaccharide (LPS) induced phosphorylation of intracellular HDAC5 and NF-κB p65 in murine macrophages. In vivo, subcutaneous injection of SAP15-loaded sodium hyaluronic acid solution significantly decreases hind paw swelling, joint inflammation, and serum cytokine levels in a collagen induced arthritis (CIA) rat model.

Please contact us for availability.

SKU: HD-010 Categories: ,

Additional information

Other Names

Peptide 3

Three Letter Sequence

H-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys-OH

Molecular Weight

1767.18

Molecular Formula

C68 H131N31O18S3

Sequence

GKCSTRGRKCCRRKK

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

SAP15, HD-010, HD010, GKCSTRGRKCCRRKK