Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

HDAC5 inhibitor.

SAP15 is a cell penetrating peptide corresponding to the last 15 amino acids of the host defense peptide human ?-defensin 3, which is involved in adaptive immunity and pro- and anti-inflammatory responses. SAP15 is a histone deacetylase 5 (HDAC5) inhibitor with a dissociation constant of 86 nM in an SPR assay and inhibits lipopolysaccharide (LPS) induced phosphorylation of intracellular HDAC5 and NF-κB p65 in murine macrophages. In vivo, subcutaneous injection of SAP15-loaded sodium hyaluronic acid solution significantly decreases hind paw swelling, joint inflammation, and serum cytokine levels in a collagen induced arthritis (CIA) rat model.

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