S9pep

£145.00 1mg

SOX9 mimetic.

S9pep is a short sequence of the transcription factor SOX-9, located at the hinge between the high mobility group (HMG) – DNA-binding domain and the SOX-E central conserved domain, that can mimic SOX9 tumour suppressive properties. Like full length SOX9, S9pep inhibits Wnt/?-catenin signaling and the expression of c-Myc, its oncogenic target gene, by relocating ?-catenin from the chromatin to the cytosol. S9pep disrupts colorectal cancer cell morphology, reduces the growth of colorectal cancer cells and stem cells, and inhibits tumour development in vivo.

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SKU: NR-180 Categories: ,

Additional information

Other Names

SOX9(208-229)

Three Letter Sequence

H-Ala-Asp-Ser-Pro-His-Ser-Ser-Ser-Gly-Met-Ser-Glu-Val-His-Ser-Pro-Gly-Glu-His-Ser-Gly-OH

Molecular Weight

2079.1

Molecular Formula

C82H123N27O35S

Sequence

ADSPHSSSGMSEVHSPGEHSG

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

S9pep, NR-180, SOX9(208-229), ADSPHSSSGMSEVHSPGEHSG