S9pep
£145.00 1mg
SOX9 mimetic.
S9pep is a short sequence of the transcription factor SOX-9, located at the hinge between the high mobility group (HMG) – DNA-binding domain and the SOX-E central conserved domain, that can mimic SOX9 tumour suppressive properties. Like full length SOX9, S9pep inhibits Wnt/?-catenin signaling and the expression of c-Myc, its oncogenic target gene, by relocating ?-catenin from the chromatin to the cytosol. S9pep disrupts colorectal cancer cell morphology, reduces the growth of colorectal cancer cells and stem cells, and inhibits tumour development in vivo.
Please contact us for availability.
Additional information
| Other Names | SOX9(208-229) |
|---|---|
| Three Letter Sequence | H-Ala-Asp-Ser-Pro-His-Ser-Ser-Ser-Gly-Met-Ser-Glu-Val-His-Ser-Pro-Gly-Glu-His-Ser-Gly-OH |
| Molecular Weight | 2079.1 |
| Molecular Formula | C82H123N27O35S |
| Sequence | ADSPHSSSGMSEVHSPGEHSG |
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | S9pep, NR-180, SOX9(208-229), ADSPHSSSGMSEVHSPGEHSG |