Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Human growth hormone receptor antagonist.

S1H is a 16-residue peptide designed as a direct sequence mimetic of the site 1 mini-helix (residues 36-51) of wild-type human growth hormone (hGH). S1H acts as an inhibitor by blocking the interaction of hGH with the human growth hormone receptor (hGHR). S1H mitigates phosphorylation of STAT5 in cells co-treated with hGH, reducing intracellular STAT5 phosphorylation levels to those of untreated controls. S1H can be used as a chemical tool to study the molecular nature of hGH hGHR interactions.

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