S1H

£135.00 1mg

Human growth hormone receptor antagonist.

S1H is a 16-residue peptide designed as a direct sequence mimetic of the site 1 mini-helix (residues 36-51) of wild-type human growth hormone (hGH). S1H acts as an inhibitor by blocking the interaction of hGH with the human growth hormone receptor (hGHR). S1H mitigates phosphorylation of STAT5 in cells co-treated with hGH, reducing intracellular STAT5 phosphorylation levels to those of untreated controls. S1H can be used as a chemical tool to study the molecular nature of hGH hGHR interactions.

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SKU: CY-010 Categories: ,

Additional information

Other Names

S1H (36-51)

Three Letter Sequence

Ac-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-Asn-Pro-Gln-Thr-NH2

Molecular Weight

2025.29

Molecular Formula

C94H141N23O27

Sequence

Ac-YIPKEQKYSFLQNPQT-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N terminal acetyl, C terminal amide

Searchable Words

S1H, Ac-YIPKEQKYSFLQNPQT-NH2, CY-010, CY010