RW4

£125.00 1mg

Antimicrobial and antifungal.

RW4 is a short peptide containing repeating arginine (R) and tryptophan (W) residues which has been shown to possess antimicrobial and antifungal activity with low cytotoxicity. The positively charged arginine interacts with the bacterial membrane through electrostatic attraction whereas the non-polar tryptophan residue interacts with the lipid bilayer. These two properties allow RW4 to interact with the bacterial membrane, resulting in membrane destabilization and pore formation and bacterial cell death. RW4 has been shown to have enhanced activity in combination with other antimicrobial agents.

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SKU: AM-152 Categories: ,

Additional information

Three Letter Sequence

H-Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2

Molecular Weight

1386.6

Molecular Formula

C86H91N25O8

Sequence

RWRWRWRW-NH2

Solubility

Soluble in dilute acid and physiological buffers

Appearance

Freeze dried solid

Storage

Store dry, dark and frozen

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

H-RWRWRWRW-NH2, RWRWRWRW-NH2, RWRWRWRW, RW4, antimicrobial, antifungal , RW 4, AM-152, AM152