RTDLDSLRTYTL

£95.00 1mg

Alpha(v) beta(6) integrin (avb6) inhibitor.

RTDLDSLRTYTL is a phage library selected high affinity 12-mer peptide with high selectivity for alpha(v) beta(6) integrin (avb6). RTDLDSLRTYTL is a selective inhibitor of RGD dependent ligand binding to avb6 in isolated receptor assays with an IC50 of 20 nM, and also in cell adhesion assays with an IC50 of 50 mM. When tested against avb6 binding to immobilized fibronectin, RTDLDSLRTYTL peptide strongly inhibits the avb6 fibronectin interaction with an IC50 of 100 nM. avb6 is a specific receptor for fibronectin which supports epithelial cell proliferation during wound healing and carcinoma progression.

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SKU: IG-020 Categories: ,

Additional information

Three Letter Sequence

H-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-Thr-Tyr-Thr-Leu-OH

Molecular Weight

1453.61

Molecular Formula

C62H104N18O22

Sequence

RTDLDSLRTYTL

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

RTDLDSLRTYTL, alpha(v) beta(6) integrin, avb6, RGD, avb6 fibronectin interaction, IG-020, IG020