Rb4

£155.00 1mg

Induces expression of HMGB1 and calreticulin.

Rb4 is a peptide derived from the N-terminal of proteolipid protein 2 (PLP2), a transmembrane lipoprotein first identified in human colonic epithelial cells. Rb4 triggers necrotic cell death in murine melanoma mainly through ER stress caused by inhibition of SERCA transporter activity, which leads to alteration of actin dynamics and RIP1 inhibition. Rb4 acts directly on tumour cells to induce the expression of two damage associated molecular pattern (DAMP) molecules, HMGB1 and calreticulin, which triggers an immunoprotective response against melanoma cells. In vivo Rb4 reduces lung metastasis of tumour cells and delays subcutaneous melanoma growth.

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Additional information

Other Names

Peptide Rb4, N-terminal PLP2 peptide

Three Letter Sequence

H-Met-Ala-Asp-Ser-Glu-Arg-Leu-Ser-Ala-Pro-Gly-Cys-Trp-Ala-Ala-Cys-Thr-Asn-Phe-Ser-Arg-Thr-Arg-Lys-NH2

Molecular Weight

2658.04

Molecular Formula

C110H177N37O34S3

Sequence

MADSERLSAPGCWAACTNFSRTRK-NH2

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

Rb4, PP-310, PP310, MADSERLSAPGCWAACTNFSRTRK-NH2, N-terminal PLP2 peptide