Prosaptide TX14(A)

£95.00 1mg

GPR37 and GPR37L1 agonist.

Prosaptide TX14(A) is derived from the active region of saposin C, itself derived from proteolytic processing of prosaposin, a 517-amino acid residue protein and neurotropic factor. Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1 with EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37. Prosaptide TX14(A) can protect primary astrocytes against oxidative stress, prolongs cell survival in both Schwann cells and oligodendrocytes and has anti-allodynic properties in a rat model of gp120-induced tactile allodynia.

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SKU: OR-010 Categories: ,

Additional information

Other Names

16-29-Saposin C, TX14(A)

Three Letter Sequence

H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH

Molecular Weight

1579.72

Molecular Formula

C69H110N16O26

Sequence

TaLIDNNATEEILY

Solubility

Soluble to 2 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

Alanine-2 is D configuration

Searchable Words

Prosaptide TX14(A), 196391-82-9, TaLIDNNATEEILY, 16-29-Saposin C, OR-010, OR010