Prosaptide TX14(A)
£95.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
GPR37 and GPR37L1 agonist.
Prosaptide TX14(A) is derived from the active region of saposin C, itself derived from proteolytic processing of prosaposin, a 517-amino acid residue protein and neurotropic factor. Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1 with EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37. Prosaptide TX14(A) can protect primary astrocytes against oxidative stress, prolongs cell survival in both Schwann cells and oligodendrocytes and has anti-allodynic properties in a rat model of gp120-induced tactile allodynia.
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Additional information
Other Names | 16-29-Saposin C, TX14(A) |
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Three Letter Sequence | H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH |
Molecular Weight | 1579.72 |
Molecular Formula | C69H110N16O26 |
Sequence | TaLIDNNATEEILY |
Solubility | Soluble to 2 mg/ml in water |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Purity | >95% by HPLC |
Modifications | Alanine-2 is D configuration |
Searchable Words | Prosaptide TX14(A), 196391-82-9, TaLIDNNATEEILY, 16-29-Saposin C, OR-010, OR010 |