Human AB Serum is a vital cell culture reagent for some human cell types. It provides growth factors, vitamins, nutrients as well as trace elements and transport factors. Thereby ensuring faster growth rates than mixed blood group serum. This product is proven to grow many human cell lines at a faster rate and with a smaller percentage of serum than mixed blood group serum. This product, along with human platelet lysate, is now widely used in a variety of Cell Therapy applications.

Human serum from type AB donors lacks antibodies against the A and B blood-type antigens. Therefore, it is commonly used when there is the need to minimize immunoreactivity. Furthermore, male-only serum is especially advantageous compared with female or mixed gender serum. This is because there is no risk of the presence of antibodies against major histocompatibility class (MHC) antigens. Those can be produced by female donors against antigens carried on the father’s cells and/or the foetus’ cells during pregnancy. 

There are two types of this product commercially available:

Converted serum is produced by defibrinating pooled human plasma that was collected via plasmapheresis, in the presence of an anticoagulant such as sodium citrate. Defibrination may be achieved using a method that requires the addition of thrombin or then methods reliant on the use of calcium. This material can also be referred to as ‘Plasma-derived’. Human AB serum ‘converted’ is available with the option to be manufactured using recombinant human thrombin or bovine thrombin, as required.

human AB serum

Off-clot serum is collected from blood that is allowed to coagulate naturally after collection. This is carried out without the addition of any anticoagulant.

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