PR 619

£65.00 5mg

Broad spectrum deubiquitinylating enzyme (DUB) inhibitor.

PR 619 is a broad spectrum, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with an EC50 of 1-20 M in a cell-free assay and only limited activity against other proteases. PR 619 induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. PR 619 is cytotoxic in HEK293T and colorectal cancer cells and stabilizes microtubule networks in oligodendroglial cells.

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SKU: PI-150 Categories: ,

Additional information

Three Letter Sequence

2,6-Diamino-3,5-dithiocyanopyridine

Molecular Weight

223.28

Molecular Formula

C7H5N5S2

Sequence

2,6-Diamino-3,5-dithiocyanopyridine

Solubility

Soluble to 10 mM in DMSO

Appearance

Light brown solid

Storage

Store desiccated, frozen and in the dark

Purity

>98% by HPLC