PR 26
£195.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
Antimicrobial.
PR 26 is the first 26 amino acid residues of the amine terminus of the functional antimicrobial domain of PR 39 (AM-110), the proline-rich cathelicidin host defence and immunomodulatory peptide isolated from porcine polymorphonuclear neutrophils. PR 26 is as least as potent as PR 39 against enteric gram negative bacteria and potentiates neutrophil phagocytosis of Salmonella choleraesuis and decreases the level of S. typhimurium invasion into intestinal epithelial cells, however PR 26 does not lyse cells by pore-forming mechanisms.
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Additional information
| Three Letter Sequence | H-Arg-Arg-Arg-Pro-Arg-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Pro-Phe-Phe-Pro-Pro-Arg-Leu-Pro-Pro-Arg-Ile-OH |
|---|---|
| Molecular Weight | 3229.9 |
| Molecular Formula | C153H242N50O28 |
| Sequence | RRRPRPPYLPRPRPPPFFPPRLPPRI |
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and desiccated |
| Purity | >95% by HPLC |
| Searchable Words | H-RRRPRPPYLPRPRPPPFFPPRLPPRI-OH, RRRPRPPYLPRPRPPPFFPPRLPPRI, PR 26, cathelicidin host defence, immunomodulatory, PR26, PR-26, AM-111, AM111 |