PLP (139-151)

£75.00 1mg

Induces severe experimental allergic encephalomyelitis (EAE).

PLP (139-151), or proteolipid protein (139-151) is a myelin proteolipid protein (PLP) fragment. PLP is one of the major protein constituents of myelin, along with myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP), which between them make up 15% – 25% of dry weight, the rest being mainly lipids. Myelin has an essential insulating role for nerves, allowing normal motor function, sensory function and cognition. Animals immunized with PLP (139-151) develop severe experimental allergic encephalomyelitis (EAE) and this model is widely used to study human multiple sclerosis (MS).

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SKU: NR-030 Categories: ,

Additional information

Other Names

Proteolipid protein (139-151)

Three Letter Sequence

H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH

Molecular Weight

1537.8

Molecular Formula

C72H104N20O16S

Sequence

HCLGKWLGHPDKF

Solubility

Soluble in dilute acid

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

PLP (139-151), proteolipid protein (139-151), myelin proteolipid protein, PLP, Myelin, experimental allergic encephalomyelitis, EAE, multiple sclerosis, MS, 131334-43-5, HCLGKWLGHPDKF, NR-030, NR030