PKI (14-22) Amide, Myristoylated
£55.00 1mg
Cell permeable protein kinase A inhibitor.
PKI (14 – 22) amide, myristoylated, is a cell-permeable version of the protein kinase inhibitor (PKI) PKI (14-22) amide. When non-myristoylated, PKI (14-22) amide inhibits protein kinase A with a Ki of 36 nM and also inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1). Myristoylated peptides as a class may exhibit off-target activation of the funny current If in sinoatrial myocytes.
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Additional information
| Three Letter Sequence | Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 |
|---|---|
| Molecular Weight | 1209.5 |
| Molecular Formula | C53H100N20O12 |
| Sequence | Myr-GRTGRRNAI-NH2 |
| Solubility | Soluble in dilute acid and DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | Myristoyl at N terminal, amide at C terminal |
| Searchable Words | 201422-03-9, Myr-GRTGRRNAI-NH2, GRTGRRNAI, PKI (14 – 22) amide, myristoylated, cell-permeable, protein kinase inhibitor, PKI, PKI (14-22) amide, protein kinase A, KS-110, KS110 |