Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

Metalloendopeptidase inhibitor.

Phosphoramidon is a metalloendopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases and also strongly inhibits mammalian enkephalinase but does not inhibit trypsin, papain, chymotrypsin or pepsin. Phosphoramidon has been used as a neprilysin (NEP) inhibitor to study amyloid beta (A?) uptake and degradation.

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