Metalloendopeptidase inhibitor.

Phosphoramidon is a metalloendopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases and also strongly inhibits mammalian enkephalinase but does not inhibit trypsin, papain, chymotrypsin or pepsin. Phosphoramidon has been used as a neprilysin (NEP) inhibitor to study amyloid beta (A?) uptake and degradation.

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