pFYN peptide

£225.00 1mg

Phosphorylated peptide substrate derived from FYN, a Src family kinase.

pFYN peptide is a phosphorylated peptide substrate derived from FYN, a member of the Src family of kinases. pFyn peptide can be used in an AlphaLISA assay for the identification and optimization of allosteric STEP (striatal-enriched protein tyrosine phosphatase) ligands. STEP is a critical regulator of glutamatergic synapse function and neuronal survival, acting on targets directly involved in regulation of synaptic plasticity such as the NMDA and AMPA receptors, as well as targets regulating these receptors, such as ERK1/2, p38, FYN, and PYK2. pFYN-peptide phosphorylated peptide substrate is used in place of the endogenous STEP substrate FYN.

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SKU: BT-010 Categories: ,

Additional information

Three Letter Sequence

Biotin-Gly-Leu-Ala-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr(H2PO3)-Thr-Ala-Arg-Gln-Gly-Ala-Lys-Phe-Pro-Ile-OH

Molecular Weight

2764.95

Molecular Formula

C115H183N32O43PS

Sequence

GLARLIEDNEYTARQGAKFPI

Solubility

Soluble in water

Appearance

Freeze dried solid

Storage

Store desiccated, frozen and in the dark

Purity

>95% by HPLC

Modifications

Biotin at N terminal glycine, tyrosine 11 is phosphorylated

Searchable Words

pFYN peptide, Biotin-GLARLIEDNE-Y(H2PO3)-TARQGAKFPI-OH, GLARLIEDNEYTARQGAKFPI, phosphorylated, substrate, Src, kinases. AlphaLISA, assay, STEP, FYN, BT-010