Pexiganan

£145.00 1mg

Broad spectrum antibacterial agent.

Pexiganan (MSI 78) is a synthetic cationic peptide and an analogue of magainin 2, the host defence peptide isolated from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many gram-positive and gram-negative, anaerobic and aerobic bacteria and is the first AMP developed into an antibacterial drug and the best-studied AMP to date for therapeutic purposes. Pexiganan shows a barrel-stave type mechanism of membrane disruption or channel formation and exerts its antibacterial effect by forming toroidal pores in bacterial membranes.

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SKU: AM-310 Categories: ,

Additional information

Other Names

MSI 78

Three Letter Sequence

H-Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-Leu-Lys-Lys-NH2

Molecular Weight

2477.21

Molecular Formula

C122H210N32O22

Sequence

GIGKFLKKAKKFGKAFVKILKK-NH2

Solubility

Soluble in DMSO and physiological buffers

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C terminal amide

Searchable Words

H-RRRPRPPYLPRPRPPPFFPPRLPPRI-OH, RRRPRPPYLPRPRPPPFFPPRLPPRI, PR 26, cathelicidin host defence, immunomodulatory, PR26, PR-26, AM-111, AM111