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Peptide5

£125.00 1mg

SKU: PN-020 Categories: , ,

Connexin43 hemichannel blocker.

Peptide5, also known as connexin43 mimetic peptide 5, was designed to bind to extracellular regions of the connexin43 (Cx43) protein, and is a blocker of Connexin43 hemichannels. Connexin43 hemichannels in spinal cord astrocytes are implicated in the maintenance of neuropathic pain following peripheral nerve injury and Peptide 5 can reduce swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury. Peptide5 exhibits analgesic effects in models of neuropathic pain.

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Additional information

Other Names

Connexin43 mimetic peptide 5
Three Letter Sequence

H-Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr-OH
Molecular Weight

1395.6
Molecular Formula

C60H98N16O20S
Sequence

VDCFLSRPTEKT
Solubility

Soluble to 2 mg/ml in water
Appearance

Freeze dried solid
Storage

Store desiccated, frozen and in the dark
Purity

>95% by HPLC
Searchable Words

H-VDCFLSRPTEKT-OH, VDCFLSRPTEKT, 916977-43-0, connexin43 mimetic peptide 5, connexin43 (Cx43) protein, Connexin43 hemichannels, neuropathic, PN-020, PN020