Pep2-8

£75.00 1mg

PCSK9 inhibitor.

Pep2-8 is a peptide from a phage library that was identified as the smallest proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitor) with a clearly defined mechanism of inhibition. Pep2-8 binds to PCSK9 with a KD of 0.7 μm but has no affinity for other proprotein convertases. Pep2-8 restores low density lipoprotein (LDL) receptor function and LDL uptake in PCSK9-treated HepG2 cells.

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SKU: OP-020 Categories: ,

Additional information

Three Letter Sequence

Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2

Molecular Weight

1715.88

Molecular Formula

C83H110N16O24

Sequence

Ac-TVFTSWEEYLDWV-NH2

Solubility

Soluble to 2 mg/ml in PBS

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

N-terminal Ac, C-terminal amide

Searchable Words

Pep 2-8, Ac-TVFTSWEEYLDWV-NH2, 1541011-97-5, Pep2-8