Pep2-8
£75.00 1mg
Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.
PCSK9 inhibitor.
Pep2-8 is a peptide from a phage library that was identified as the smallest proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitor) with a clearly defined mechanism of inhibition. Pep2-8 binds to PCSK9 with a KD of 0.7 μm but has no affinity for other proprotein convertases. Pep2-8 restores low density lipoprotein (LDL) receptor function and LDL uptake in PCSK9-treated HepG2 cells.
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Additional information
| Three Letter Sequence | Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 |
|---|---|
| Molecular Weight | 1715.88 |
| Molecular Formula | C83H110N16O24 |
| Sequence | Ac-TVFTSWEEYLDWV-NH2 |
| Solubility | Soluble to 2 mg/ml in PBS |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N-terminal Ac, C-terminal amide |
| Searchable Words | Pep 2-8, Ac-TVFTSWEEYLDWV-NH2, 1541011-97-5, Pep2-8 |