Pep2-8
£75.00 1mg
PCSK9 inhibitor.
Pep2-8 is a peptide from a phage library that was identified as the smallest proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitor) with a clearly defined mechanism of inhibition. Pep2-8 binds to PCSK9 with a KD of 0.7 μm but has no affinity for other proprotein convertases. Pep2-8 restores low density lipoprotein (LDL) receptor function and LDL uptake in PCSK9-treated HepG2 cells.
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Additional information
| Three Letter Sequence | Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 |
|---|---|
| Molecular Weight | 1715.88 |
| Molecular Formula | C83H110N16O24 |
| Sequence | Ac-TVFTSWEEYLDWV-NH2 |
| Solubility | Soluble to 2 mg/ml in PBS |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | N-terminal Ac, C-terminal amide |
| Searchable Words | Pep 2-8, Ac-TVFTSWEEYLDWV-NH2, 1541011-97-5, Pep2-8 |